Drug release study of an herbicide from polymeric microspheres and disks. Calcul of diffusivities

 

 Z. El Bahri1*, K. Diaf1, J-L. Taverdet2, N. Chafi1

1 Laboratoire de Chimie Organique Physique et Macromoléculaire, Faculté des Sciences,

Université Djillali Liabès de Sidi Bel Abbès 22000, Algérie.

2 Laboratoire Chimie et Environnement, Université Jean Monnet, 23 Rue Paul Michelon, 42023 Saint-Etienne Cedex 02, France.

* Corresponding author. E-mail:  elbahrizineb@yahoo.fr

Received: 10 May 2008; revised version accepted: 22 July 2009

 

Abstract 

     Microspheres and disks composed from 2,4-D as drug and cellulose derivatives as matrixes are prepared by solvent evaporation techniques. The microspheres are obtained by the microencapsulation process ie. emulsion solvent evaporation whereas the disks are obtained by simple evaporation of solvent from organic solution. The drug loaded microspheres are characterized by scanning electron microscopy and infrared spectroscopy and the size and size distribution are determined. The drug release from microspheres and disks is established in deionized water at 25°C. The release mechanism of the active agent is investigated according to Fick’s laws and the diffusivities in microspheres and disks are calculated and compared.

 

Keywords: microspheres; disk; cellulose derivatives; 2,4-D; drug release, diffusion.


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