SYNTHESIS OF NOVEL BENZIMIDAZOLYL

AND QUINOLINYL COUMARINS

 

K.Y.G. Molou, A. Adjou*, M.V. Say, D. Sissouma, S. A. Touré, G. C. Téa

Laboratoire de Chimie Organique Structurale – UFR SSMT – Université Félix Houphouët-Boigny.

22 B.P. 582 Abidjan 22 – République de Côte d’Ivoire

* Corresponding author. E-mail: adjouane@hotmail.com

Received: 17 October 2013; revised version accepted: 09 December 2013

 

Abstract

     The coupling of coumarin-3-carboxylic acid 4 or 4-oxo-dihydroquinolin-3-carboxylic acid 10 and its N-ethyl derivatives 12 with o-phenylenediamine and its analogs was accomplished by Phillips reaction. 2-Mercaptobenzimidazoles and its analogs 18 react with acid chloride derivatives to give benzimidazoylcoumarins or quinolinylcoumarins having a thio carbonyl link between coumarin and benzimidazole cores.

The structures of the synthesized compounds were proved by means of 1H, 13C NMR and mass spectral data.

 

Keywords: Coumarins; Quinolin-3-one; O-phenylenediamine; Benzimidazole.


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