QSAR for anti-malarial products
M. Zahouily*, M. Lazar
UFR Chimie Appliquée, Laboratoire de Catalyse, Chimiométrie et Environnement, Département de Chimie,
Faculté des Sciences et Techniques, B.P. 146, Mohammadia 20650, Maroc
* Corresponding author. E-mail:firstname.lastname@example.org
Received: 26 December 2004; revised version accepted:18 August 2006
Quantitative structure-activity antimalarial relationships were studied for 63 analogues of 2-Aziridinyl and 2.3-bis(azidirinyl)-1.4-naphthoquinonyl sulfonate and acylate derivatives by means of multiple linear regression (MLR). The antimalarial activity (-logIC50x106) of the compounds studied were well correlated with the descriptors encoding the chemical structure. The results showed that the antimalarial activity of
Keywords: 2D-QSAR; Anti-malarial activity; Pertinent descriptors; MLR.