Synthesis of New derivatives of principal constituent

of pennyroyal oil by cleavage of oxiranes with TiCl4

L. Majidi1*, Z. Faska1, A. Bellioua1, H. Abraoui1, S. Kharchouf1,  R. Fihi1, M. Hnach2

1Equipe  des Substances Naturelles & Synthèse et Dynamique Moléculaire,

UFR Valorisation des Substances Naturelles et environnement,

Faculté des Sciences et Techniques, Département de Chimie, Errachidia, Morocco

2 Département de Chimie, Faculté des Sciences, Meknès, Morocco

* Corresponding author. E-mail:  lmajidi@yahoo.fr

Received: 20 February 2007; revised version accepted:15 October 2008

 

Abstract

     A novel and short synthetic method for the stereoselective synthesis of allylic syn a,b-diols and halohydrines has been developed by an unusual cleavage of epoxides with TiCl4.

 

Keywords: Pulegone; Allylpulegols; Epoxides; cleavage; Steroselectivity; Regioselectivity; a,b-diold; Halohydrines.

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