CATALYTIC OXIDATION OF CATECHOL BY NEW IRON COMPLEXES MODLED AFTER THE METAL BINDING SITE OF BLEOMYCIN
A. Amine1*, Z. Atmani1, M. Pierrot2, M. Réglier2
1.Univérsité My Ismail, Faculté des Sciences de Meknès, Laboratoire de Chimie Organique Appliquée, Meknès, Maroc.
2.Université Aix-Marseille III, Faculté des Sciences et Techniques saint Jérôme, Laboratoire de Bioinorganique Structurale, Marseille, France.
* Corresponding author. E-mail: Amine@fsmek.ac.ma
Received : 24 July 2001; revised version accepted 04 February 2002
The catalytic efficiency of new models for the metal binding subunit of bleomycin in the oxidation of 3,5-di-tert-butylcatechol to its corresponding quinone was studied using UV-V is absorption spectra methods. All studied complexes exhibit catalytical activity in this reaction. Kinetics of the oxidation of 3,5-di-tert-butylcatechol were determined by the method of initial rates and a kinetic treatment on the basis of Michaelis-Menten model was then applied.
Keywords: Iron complexes; Catecholase activity; Oxidation; Bleomycin Models.