CATALYTIC OXIDATION OF CATECHOL BY NEW IRON COMPLEXES MODLED AFTER THE METAL BINDING SITE OF BLEOMYCIN

A. Amine1*, Z. Atmani1, M. Pierrot2, M. Réglier2

1.Univérsité My Ismail, Faculté des Sciences de Meknès, Laboratoire de Chimie Organique Appliquée, Meknès, Maroc.

2.Université Aix-Marseille III, Faculté des Sciences et Techniques saint Jérôme, Laboratoire de Bioinorganique Structurale, Marseille, France.

* Corresponding author. E-mail: Amine@fsmek.ac.ma

Received : 24 July 2001; revised version accepted 04 February 2002

Abstract

The catalytic efficiency of new models for the metal binding subunit of bleomycin in the oxidation of 3,5-di-tert-butylcatechol to its corresponding quinone was studied using UV-V is absorption spectra methods. All studied complexes exhibit catalytical activity in this reaction. Kinetics of the oxidation of 3,5-di-tert-butylcatechol were determined by the method of initial rates and a kinetic treatment on the basis of Michaelis-Menten model was then applied.

Keywords: Iron complexes; Catecholase activity; Oxidation; Bleomycin Models.

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